synthesis and evaluation of chitosan manganese-ferrite nanoparticles as mri contrast agent

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abstract

magnetic nanoparticles are the good choice for using in mri as the contrast agent. iron oxide particles such as magnetite (fe3o4) or its oxidized form maghemite (γ-fe2o3) are the most commonly employed in biomedical applications. in this study, we synthesized and optimized the preparation of chitosan manganese-ferrite nanoparticles (cmn-fe nps) and evaluated its ability for the mice macrophage cells imaging with mri. the core and hydrodynamic size of the nanoparticles was 54±27 nm and 149±48 nm respectively. the magnetization reached a saturation magnetization value of 95 emu/g. the mri images showed that the liver and some other organs were accumulated the cmn-fe nps and produced a negative contrast in images. cmn-fe nps demonstrated that it is a good candidate for using as a contrast agent material in macrophage cells imaging with mri.

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Journal title:
international journal of bio-inorganic hybrid nanomaterials

جلد ۴، شماره ۳، صفحات ۱۵۵-۱۵۹

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